Humanized Mouse Models for Transplant Immunology
نویسندگان
چکیده
منابع مشابه
Humanized Mouse Models for Transplant Immunology.
Our understanding of the molecular pathways that control immune responses, particularly immunomodulatory molecules that control the extent and duration of an immune response, have led to new approaches in the field of transplantation immunology to induce allograft survival. These molecular pathways are being defined precisely in murine models and translated into clinical practice; however, many...
متن کاملHumanized Mouse Models of Staphylococcus aureus Infection
Staphylococcus aureus is a successful human pathogen that has adapted itself in response to selection pressure by the human immune system. A commensal of the human skin and nose, it is a leading cause of several conditions: skin and soft tissue infection, pneumonia, septicemia, peritonitis, bacteremia, and endocarditis. Mice have been used extensively in all these conditions to identify virulen...
متن کاملInside transplant immunology.
The two-step matching process When an organ offer is made, a second cascade of screening events occurs. LifeLink Transplantation Immunology Laboratory in Tampa, FL, performs real-time nucleic-acid testing (NAT), which allows for the detection of HIV, West Nile virus, and hepatitis B genetic material. NAT is a more stringent protocol than simply testing the body’s response to an infectious disea...
متن کاملAspects of Corneal Transplant Immunology
249 Eduard Zirm performed the first successful allogeneic corneal transplant in 1905,[1] making this corneal graft a pioneering event in early organ transplantation.[2] Despite this long history, our knowledge of corneal immune function and graft rejection pathophysiology and its prevention are lagging in comparison to solid organ transplantation. This is, to some extent, due to a misunderstand...
متن کاملHumanized NSG Mouse Models of HIV-1 Infection and Pathogenesis
J Hum Virol Retrovirol 2016, 3(2): 00087 Another alternative approach has been to implant human stem cells (HSC) into newborn NSG mice. Both models provide a suitable environment in which to partially reconstitute the human immune system. With adequate numbers of target cells, HIV-1 can replicate without interference from the mouse immune system. The NSG mouse transplantation/engraftment models...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2015
ISSN: 1600-6135
DOI: 10.1111/ajt.13520